Endocrine Abstracts

Introduction: Tendency to store lipids centrally is well connected to development of diabetes mellitus type 2 (T2DM) and cardiovascular morbidity. Providing insight in this process is important.Method: Relationship between radius of waist line and thickness of subcutaneous adipose tissue (SAT) was compared among forty obese patients (BMI> 30 kg/m2) in the light of their glycemic control parameters (fasting glucose, HOMA IR, HOMA beta).Pati...

Introduction: Subclinical and clinical primary hypothyroidism potentially makes a negative influence on the patient’s quality of life. Present study examined the level of hypothyroid symptoms and signs expression as well patient’s quality of life before levothyroxine and after substitutionally-induced laboratory euthyroidism.Material and methods: Prospective case–control study consisted of 75 female patients divided into three groups based...

Objective: Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with high-normal TSH levels (TSH <10 mU/l), may have mild hypothyroidism (subclinical hypothyroidism) and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD) in persons with subclinical hypothyroidism.Design: A cross-sectional study.<p class="abst...

Background: Ret protooncogene germ-line mutations are associated with the inherited multiple endocrine neoplasia type 2 syndromes (MEN2a and MEN2b) and also with familial medullary thyroid carcinoma (FMTC). In this study, we report a large scale of mutations in exon 10, 11, 13 and 14 RET protoocogene in patients from Serbia. Our study included patients with MTC.Methods: Our study included 180 patients. Patients were tested for RET protooncogene mutations...

Background: Several polymorphisms of glucocorticoid receptor (GR) gene, including BclI, N363S and ER22/23EK, which may have an influence on glucocorticoid sensitivity, have been reported. BclI and N363S polymorphisms have been associated with clinical characteristics of increased and ER22/23EK of decreased glucocorticoid (GC) effects. On the other hand, metabolic syndrome has been described in patients with adrenal incidentalomas.Objective ...

A 34 year-old female patient was admitted to the hospital because of a large nodule in the left thyroid lobe and elevated calcitonine level. A large encapsulated tumor was found and total thyroidectomy with left neck dissection was performed. Pathohistology revealed medullary and papillary carcinoma separate from each other in tumor tissue but mixed in regional lymph nodes. Papillary component was dominant in thyroid tissue but not in lymph nodes. Both calcitonine and thyroglo...

Although primary hyperparathyroidism (PHPT) can be successfully cured by parathyroidectomy (PTX) and indications for surgery are well defined, a considerable number of patients do not get operated on. By evaluating referrals for PTX in our academic hospital, we might improve our approach to the care of these patients. We retrospectively reviewed patients’ hospital records with newly diagnosed PHPT between 2014 and 2020. Biochemical and clinical parameters along with resul...

BackgroundIn 2008 EUGOGO (European group on Graves’ orbitopathy) published consensus statement on the management of Graves’ orbitopathy (GO) that was widespread ever since. Having in mind unknown general perception and practical usage of the statement amongst Croatian clinicians, we conducted a survey evaluating the awareness and practical usage of the EUGOGO guidelines among physicians treating Graves’ disease in daily practice. Also, the...

Introduction: In congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD), large CyP21A2 deletions can also affect the adjacent tenascin-X (TNXB) gene. In patients with or without 21-OHD, pathogenic variants in the TNXB gene cause Ehlers-Danlos syndrome (EDS), a connective tissue dysplasia associated with cardiovascular complications. CAH in conjunction with TNXB-dependent EDS has been termed CAH-X. This study aims to c...

Objectives: Finding novel tumor markers capable to recognize aggressive papillary thyroid carcinoma (PTC) forms are of great importance. We evaluated hsa-microRNA-204-3p (miR-204-3p) for differential diagnosis of thyroid tumors and assessed its prognostic usefulness.Methods: MiR-204-3p levels were determined in 77 PTC cases of diverse histological variants, 12 cases of follicular thyroid adenoma (FTA), and 89 matched nonmalignant thyroid epithelial tissu...